飞秒激光与角膜板层刀辅助LASIK术后早期角膜生物力学变化的比较

tyz · 发表于 2015-7-9 11:54:27

飞秒激光与角膜板层刀辅助LASIK术后早期角膜生物力学变化的比较
Comparison of corneal biomechanical changes at early stage after femtosecond LASIK and microkeratome LASIK
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飞秒激光与角膜板层刀辅助LASIK术后早期角膜生物力学变化的比较.pdf (591.95 KB, 下载次数: 0)
作　　者：李仲佶李雪杜春宇胡琦吴琼杨帆
Zhong-Ji Li, Xue Li, Chun-Yu Du, Qi Hu, Qiong Wu, Fan Yang （Optometry Center, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China）
机构地区：哈尔滨医科大学附属第一医院眼科医院视光学中心,中国黑龙江省哈尔滨市150001
出　　处：《国际眼科杂志》 2015年第15卷第3期 428-431页,共4页
International Journal of Ophthalmology
基　　金：黑龙江省哈尔滨市科技创新人才研究专项资金项目（No.2010RFLXS010）; 黑龙江省教育厅科学技术专项资金项目（No.12521263）; 黑龙江省人事厅留学回国人员科技项目择优资助资金项目（No.2012-134）.
摘　　要：目的：基于角膜基质床厚度/术前角膜厚度（residual corneal stroma thickness/corneal thickness,RCST/CT）的不同,比较飞秒激光辅助LASIK和角膜板层刀辅助LASIK术后早期角膜生物力学的变化。方法：选取190例379眼,其中飞秒激光辅助LASIK组94例187眼,角膜板层刀辅助LASIK组96例192眼。根据术后剩余RCST/CT的不同,将飞秒激光辅助LASIK组（FS-IK组）和角膜板层刀辅助LASIK组（M-IK组）各分为三组,IK-Ⅰ组（RCST/CT〈55%）、IK-Ⅱ组（55%≤RCST/CT〈60%）和IK-Ⅲ组（RCST/CT≥60%）。分别于术前、术后1mo和3mo应用眼反应分析仪（reichert ocular response analyzer,ORA）检测角膜滞后量（corneal hysteresis,CH）和角膜阻力因子（corneal resistance factor,CRF）。结果：不同手术方式（FS-IK与M-IK）比较,CH和CRF均无统计学差异（F=0.44,F=2.56,P=0.51,P=0.11）。不同的RCST/CT比较,CH和CRF均有统计学差异（F=103.03,128.48,P均〈0.05）。Ⅰ组CH和CRF较Ⅱ组明显减小（P〈0.05）,Ⅱ组CH和CRF较Ⅲ组明显减小（P〈0.05）,Ⅰ组CH和CRF较Ⅲ组明显减小（P〈0.05）。术前及术后不同时间比较,CH和CRF均有统计学差异（F=576.99,1162.06,P均〈0.05）。术后1mo和3mo,CH和CRF均较术前明显减小（P〈0.05）,术后1mo和术后3mo比较,CH和CRF差异无统计学意义（P〉0.05）。结论：无论是飞秒激光辅助LASIK还是角膜板层刀辅助LASIK在术后早期角膜生物力学参数均下降,但两种手术方式对角膜生物力学的影响无差异。LASIK术后保留角膜基质床比例越小对角膜生物力学的影响越大。
AIM： To compare the corneal biomechanical changes at early stage after femtosecond laser assisted in situ keratomi（ LASIK） and microkeratome LASIK according to different residual corneal stroma thickness /cornea thickness（ RCST/CT）.METHODS： Ninety- four patients（ 187 eyes） with femtosecond LASIK（ FS- IK） and 96 patients（ 192 eyes）with microkeratome LASIK（ M- IK） were included in this study. LASIK group was divided into three groups according to the ratio of RCST/CT,which were IK- I group（ RCST/CT 〈55%）,IK-Ⅱ group（ 55%≤RCST/CT〈60%） and IK- Ⅲ group（ RCST/CT≥60%）. Corneal hysteresis（ CH） and corneal resistance factor（ CRF） were measured by reichert ocular response analyzer（ ORA） at pre- operation,postoperative 1and 3mo.RESULTS： Compared with FS- IK and M- IK,there were no statistical difference in CH and CRF（ F =0. 44,F =2. 56,P = 0. 51,P = 0. 11）. Based on different RCST/CT,there were statistical differences in CH and CRF between group Ⅰ and group Ⅱ（ F = 103. 03,128. 48,P〈0. 05）,group Ⅱ and group Ⅲ（ P〈0. 05）,group Ⅰ and group Ⅲ（ P〈0. 05）. There were statistical differences in CH and CRF between pre- operation and different postoperative times（ F = 576. 99,1162. 06,P〈0. 05）. CH and CRF of postoperative 1mo and 3mo were significantly smaller than pre- operation（ P〈0. 05）,but there was no statistical difference between postoperative 1and 3mo（ P 0.05）.CONCLUSION： The biomechanical parameters decreased at early stage after femtosecond LASIK and microkeratome LASIK,but there is no statistical difference between femtosecond LASIK and microkeratome LASIK.The less the ratio of RCST/CT, the more effect on biomechanics.
关键词：飞秒激光角膜板层刀准分子激光原位角膜磨镶术角膜生物力学
femtosecond laser ; microkeratome ; LASIK ; corneal biomechanics ;

[技术] 飞秒激光与角膜板层刀辅助LASIK术后早期角膜生物力学变化的比较

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